Whole Genome Sequencing – Next Step?

The first human genome was sequenced in April 2003: Human Genome Project

This achievement is celebrated annually on DNA DAY, 25th April. Also celebrated on DNA DAY is the discovery of the double-helix structure of the chromosome by Francis Crick and James Watson in 1953. Rosalind Franklin, although not acknowledged in the awarding of the Nobel Prize to Crick and Watson, was associated with the discovery.

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The first Irish Genome was sequenced in 2010:

Irish Genome Sequenced, Revealing Early Celtic Origins

In 2015, the first Ancient Irish Genome was sequenced:

Scientists Sequence First Ancient Irish Human Genomes

The cost of Whole Genome Sequencing (WGS) has come down to under $1000 by 2017.

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Image courtesy of the NIH.

Until recently, we genetic genealogists thought about yDNA (y-chromosome DNA) testing, atDNA (autosomal DNA)  testing, mtDNA (mitochondrial DNA) testing and not forgetting X-DNA testing, as separate types of DNA testing. They are all distinct types of DNA but with whole genome sequencing, these could now all be purchased in one package.

In fact, www.YSEQ.net is doing just this with its latest offering “YSEQ’s Whole Genome Test (15x)”.

The quality of the sequencing and balancing this with the cost per genome will be important factors for genetic genealogists. Being able to use pre-existing sites for comparing results with those of other people will also be a factor. I have some learning to do on all of this!

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2 Responses to Whole Genome Sequencing – Next Step?

  1. N.Or.Dau says:

    Full Genomes offered Whole Genome Test 20x for $850 in 2016 but somehow you didn’t mention it.

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